Blar i forfatter "Ellonen, Pekka"

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    • Gender-specific associations between saliva microbiota and body size 

      Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka; de Vos, Willem M.; Eriksson, Johan G.; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-10)
      <i>Objective</i>: The human intestinal microbiota likely play an important role in the development of overweight and obesity. However, the associations between saliva microbiota and body mass index (BMI) have been sparsely studied. The aim of this study was to identify the associations between saliva microbiota and body size in Finnish children.<p> <p><i>Methods</i>: The saliva microbiota of ...

    • Genome-wide DNA methylation in saliva and body size of adolescent girls 

      Rounge, Trine Ballestad; Page, Christian; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina K; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-20)
      Aim:<br>We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents.<br>Materials & methods:<br>Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing.<br> ...

    • Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling 

      Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka; de Vos, Willem M.; Eriksson, Johan Gunnar; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-18)
      Culture-independent molecular techniques and advances in next generation sequencing (NGS) technologies make large-scale epidemiological studies on microbiota feasible. A challenge using NGS is to obtain high reproducibility and repeatability, which is mostly attained through robust amplification. We aimed to assess the reproducibility of saliva microbiota by comparing triplicate samples. The ...